Model reduction and analysis: A case study of a malaria control model

Abstract

Globally rising cases of malaria have prompted concentrated efforts to control malaria transmission, utilising various mathematical models to support the Roll Back Malaria agenda. Many existing models with their specific modifications exhibit rigidity, limiting their application to inform malaria control interventions. This study addresses this limitation by employing a reduction technique on a comprehensive malaria control model to derive a simplified system that preserves the essential dynamics of the original system. We validate the accuracy of the reduced model by comparing the two models via Bayesian MCMC. Based on a simulation study, parameter identifiability analysis and sensitivity a..